Risk-Based Mammography Screening—Promises and Challenges

examine breast cancer outcomes among a simulated cohort of women undergoing breast cancer screening strategies with the starting age and frequency of mammography tailored to their 5-year breast cancer risk.The study compares outcomes from these risk-based strategies with outcomes from traditional age-based screening approaches such as those recommended by the United States Preventive Services Task Force (USPSTF). 2Overall, the authors find that some risk-stratified screening strategies were associated with maintained or improved breast cancer mortality gains compared with age-based screening, as well as reduced falsepositive results.The study by Alagoz and coauthors 1 uses 3 breast cancer simulation models from the widely known Cancer Intervention and Surveillance Modeling Network (CISNET) to examine a cohort of US women older than 40 years without a prior history of breast cancer.The authors use the commonly