Nrf2/HO-1–dependent inhibition of ferroptosis underlies the antioxidant effects of 5-O-methylvisammioside in colitis
MeV alleviates experimental colitis, at least in part by activating Nrf2/HO-1 to restrain ferroptosis and preserve epithelial barrier integrity. These findings nominate MeV as a ferroptosis-targeting candidate for colitis.
Authors
- Fagang Xu
- Chuan Jiang (ORCID: https://orcid.org/0000-0001-7049-4569)
- Chao Gu (ORCID: https://orcid.org/0000-0002-7128-8721)
- Zhong-An Guan
- Donglin Li
- Wei Wang
- Wenwen Cui
Institutions
- Shandong University of Traditional Chinese Medicine (CN)
- Wenzhou Medical University (CN)
- Dongyang People's Hospital (CN)
- Affiliated Hospital of Shandong University of Traditional Chinese Medicine (CN)
Publication Details
- Journal
- Frontiers in Immunology
- Published
- 2026-01-20
- DOI
- https://doi.org/10.3389/fimmu.2025.1738408
- Primary Topic
- Ferroptosis and cancer prognosis
- Type
- article
- Field-Weighted Citation Impact
- 0.00