Case Report: A rare and recurrent case of primary corneal keratosis: diagnostic and therapeutic challenges

This case describes a rare presentation of primary recurrent corneal keratosis with benign histopathological features but clinically aggressive behavior. The rapid and persistent recurrence despite conservative management highlights the limitations of superficial debridement and suggests the presence of subclinical disease within the lesion base. This report underscores the need for long-term surveillance and consideration of more definitive treatment strategies for similar recurrent keratotic lesions on the cornea.

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Publication Details

Journal
Frontiers in Medicine
Published
2026-01-20
DOI
https://doi.org/10.3389/fmed.2025.1678333
Primary Topic
Nonmelanoma Skin Cancer Studies
Type
article
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article

Case Report: A rare and recurrent case of primary corneal keratosis: diagnostic and therapeutic challenges

lihong huang, Dazheng Zhang
Frontiers in Medicine
Nonmelanoma Skin Cancer Studies
article

Case Report: A rare and recurrent case of primary corneal keratosis: diagnostic and therapeutic challenges

lihong huang, Dazheng Zhang
article en

Abstract

This case describes a rare presentation of primary recurrent corneal keratosis with benign histopathological features but clinically aggressive behavior. The rapid and persistent recurrence despite conservative management highlights the limitations of superficial debridement and suggests the presence of subclinical disease within the lesion base. This report underscores the need for long-term surveillance and consideration of more definitive treatment strategies for similar recurrent keratotic lesions on the cornea.

Frontiers in MedicineVol. 12
Wuhan Prevention and Treatment Center for Occupational Diseases (CN), People's Hospital of Shiyan (CN), Chengdu University of Traditional Chinese Medicine (CN)
Gender equality
Openalex Percentile: Top 83%
Nonmelanoma Skin Cancer Studies
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Case Report: A rare and recurrent case of primary corneal keratosis: diagnostic and therapeutic challenges — lihong huang, Dazheng Zhang · Frontiers in Medicine (2026) | TGRS Research Map | TGRS