Optimizing metagenomic next-generation sequencing in CNS infections: a diagnostic model based on CSF parameters

CSF cell count and protein are reliable predictors of mNGS positivity. The model for practice showed consistent diagnostic performance and may aid in guiding precision mNGS testing, particularly in resource-constrained settings.

Authors

Institutions

Publication Details

Journal
Frontiers in Cellular and Infection Microbiology
Published
2026-01-20
DOI
https://doi.org/10.3389/fcimb.2025.1681643
Primary Topic
Bacterial Infections and Vaccines
Type
article
Field-Weighted Citation Impact
0.00
Controls
|||
ALL TIME
JAN
FEB
MAR
APR
MAY
JUN
JUL
AUG
SEP
OCT
article

Optimizing metagenomic next-generation sequencing in CNS infections: a diagnostic model based on CSF parameters

Hua-dong Meng, Chong-jian Huang, Xiao Zhu, Jun-xi Ni et al.
Frontiers in Cellular and Infection Microbiology
Bacterial Infections and Vaccines
article

Optimizing metagenomic next-generation sequencing in CNS infections: a diagnostic model based on CSF parameters

Hua-dong Meng, Chong-jian Huang, Xiao Zhu, Jun-xi Ni, Xiao-guang Cao
article en

Abstract

CSF cell count and protein are reliable predictors of mNGS positivity. The model for practice showed consistent diagnostic performance and may aid in guiding precision mNGS testing, particularly in resource-constrained settings.

Frontiers in Cellular and Infection MicrobiologyVol. 15
Anhui Medical University (CN), Suzhou Municipal Hospital (CN), Anhui Provincial Hospital (CN), First Affiliated Hospital of Anhui Medical University (CN), Third People's Hospital of Hefei (CN)
Good health and well-being
Openalex Percentile: Top 83%
Bacterial Infections and Vaccines
DOIOpen Access PDFOpenAlex
AI Navigator

Ask Laika to Summarize, Analyze, and Connect papers live on the map.

Summarize Papers & Methodologies

Extract key findings, datasets, and comparative methods across publications.

Benchmark Rankings & Visual Analytics

Rank top research institutions, authors, funders, topics, and journals by Field-Weighted Citation Impact (FWCI) and paper volume with instant charts.

Connect Distant Disciplines

Bridge topological clusters on the map to find hidden collaborative intersections.

Optimizing metagenomic next-generation sequencing in CNS infections: a diagnostic model based on CSF parameters — Hua-dong Meng, Chong-jian Huang, et al. · Frontiers in Cellular and Infection Microbiology (2026) | TGRS Research Map | TGRS