Co-expression of cancer stem cell markers CD24 and CD133 in gastric cancer tissues: Clinicopathological and prognostic significance

CD24 and CD133 exhibit high positive detection rates in GC tissues, and their co-positivity is closely associated with tumor stage progression and significantly indicates unfavorable survival outcomes. The co-expression of CD24/CD133 may reflect higher aggressiveness and metastatic potential of GC, serving as a potential prognostic marker and a direction for targeted therapeutic strategies. However, as this is a single-center retrospective study with limitations such as patient loss to follow-up and sample size, further prospective, multicenter, and mechanistic studies are required to validate its clinical applicability and biological role.