PLA2R1-mediated ERK-Dependent ferroptosis: A key pathogenic mechanism in epileptic neuronal injury
This study identified the PLA2R1-MEK-ERK-ferroptosis signaling axis, suggesting that PLA2R1 contributes to neuronal ferroptosis through ERK pathway activation in epilepsy. PLA2R1's druggability and ERK inhibitors' clinical safety provide foundation for therapeutic translation.
Authors
- Qiannan Song (ORCID: https://orcid.org/0000-0001-5751-6612)
- Hong Chen
- Guohang Wu
Institutions
- Heilongjiang University of Chinese Medicine (CN)
- First Affiliated Hospital of Heilongjiang University of Chinese Medicine (CN)
Publication Details
- Journal
- Experimental Cell Research
- Published
- 2026-01-20
- DOI
- https://doi.org/10.1016/j.yexcr.2026.114904
- Primary Topic
- Ferroptosis and cancer prognosis
- Type
- article
- Field-Weighted Citation Impact
- 0.00