Hypoxia facilitates triple-negative breast cancer stem cells enrichment and stemness maintenance through oxidized ataxia telangiectasia mutated-induced one-carbon metabolism
Hypoxia-induced oxidized ATM maintains TNBC-CSC stemness by promoting c-Myc-dependent upregulation of MTHFD2 and SHMT2, linking hypoxia, redox signaling, and one-carbon metabolism. These findings suggest a potential therapeutic axis that could be exploited for TNBC treatment.
Authors
- Ran Han (ORCID: https://orcid.org/0000-0001-8785-6693)
- Shuhui Wang (ORCID: https://orcid.org/0000-0003-4546-5664)
- Su-Hua Chen
- Hua Zhang
- Yu-Lian Ou
- Dan Yang
- Hong-Jun Jin
Institutions
- Guizhou Provincial People's Hospital (CN)
Publication Details
- Journal
- World Journal of Stem Cells
- Published
- 2026-01-20
- DOI
- https://doi.org/10.4252/wjsc.v18.i1.112278
- Primary Topic
- Cancer, Hypoxia, and Metabolism
- Type
- article
- Field-Weighted Citation Impact
- 0.00