Impact of Loop Diuretics on Long-Term Kidney Outcome
Withdrawal of RASi was associated with a steeper decline in eGFR over 3-years in those not receiving loop diuretics but this was not observed in those who were taking loop diuretics. Patients receiving loop diuretics had a high mortality. These data support the need for randomised trials investigating the efficacy and safety of loop diuretics in patients with advanced CKD.
Authors
- Samir Mehta (ORCID: https://orcid.org/0000-0001-7096-513X)
- Sunil Bhandari (ORCID: https://orcid.org/0000-0002-2748-3095)
- Natalie Ives (ORCID: https://orcid.org/0000-0002-1664-7541)
- Paul Cockwell
Institutions
- Queen Elizabeth Hospital Birmingham (GB)
- Hull University Teaching Hospitals NHS Trust (GB)
- British Heart Foundation (GB)
- Cancer Research UK Clinical Trials Unit (GB)
- Hull York Medical School (GB)
- University of Birmingham (GB)
Publication Details
- Journal
- Kidney360
- Published
- 2026-01-20
- DOI
- https://doi.org/10.34067/kid.0000001080
- Primary Topic
- Chronic Kidney Disease and Diabetes
- Type
- article
- Field-Weighted Citation Impact
- 0.00