Monocolonization with <i>Bacteroides thetaiotaomicron</i> exerts region-specific effects on Alzheimer’s disease-related traits in the murine brain
The gut microbiome has been reported to not only contribute to diseases of the gastrointestinal tract but also to interfere with and potentially even initiate diseases of other organ systems, such as the brain. Interference with the gut microbiome has been shown to elicit cognitive changes, for example, in rodent models of AD. Colonization with the common gut microbe <i>B. theta</i> not only affected the brain <i>per se</i> in our study but also showed specific brain region-dependent effects related to AD. This implies that evaluating the impact the microbiome might have on brain disorders needs a much more detailed investigation in the future with spatial and also potentially time resolution.
Authors
- Simone Stegmüller (ORCID: https://orcid.org/0000-0002-5672-7618)
- Simone Eggert (ORCID: https://orcid.org/0000-0002-6792-5556)
- Vu Thu Thuy Nguyen (ORCID: https://orcid.org/0000-0002-2484-9709)
- Stefan Kins (ORCID: https://orcid.org/0000-0002-7231-4872)
- Zukaa Al Taleb
- Henning Formes
- Elke Richling (ORCID: https://orcid.org/0000-0001-5746-8032)
- Svenja König (ORCID: https://orcid.org/0009-0008-4045-5110)
- Kristina Endres (ORCID: https://orcid.org/0000-0002-1099-8287)
- Christoph Reinhardt (ORCID: https://orcid.org/0000-0001-7002-8533)
- Yannik Schermer
- Bernd Bufe
- Florian Steinert
Institutions
- University of Kaiserslautern (DE)
- Johannes Gutenberg University Mainz (DE)
- University Medical Center of the Johannes Gutenberg University Mainz (DE)
- German Centre for Cardiovascular Research (DE)
- Max Planck Institute for Multidisciplinary Sciences (DE)
- University of Applied Sciences Kaiserslautern (DE)
Publication Details
- Journal
- Microbiology Spectrum
- Published
- 2026-01-20
- DOI
- https://doi.org/10.1128/spectrum.00744-25
- Primary Topic
- Gut microbiota and health
- Type
- article
- Field-Weighted Citation Impact
- 0.00