Defining immune-active mechanisms of PDL1V in translational ADC development

“Our observation of synergistic antitumor activity at multiple nonclinical doses supports that PDL1V allows the functional activation and trafficking of PD-L1-positive cytotoxic immune cells within a wide therapeutic window.”Lauren Coyle (Launch Commissioning Editor, Bioconjugate Insights) speaks with Megan Atkins (Senior Scientist, Translational Pharmacology, Pfizer) about advancing PDL1V from non-clinical characterization to pivotal trials, and how deeper immune profiling is reshaping the future of immune-active ADCs.

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Publication Details

Journal
Bioconjugation Insights
Published
2026-01-19
DOI
https://doi.org/10.18609/bci.2026.001
Primary Topic
Cancer Immunotherapy and Biomarkers
Type
article
Field-Weighted Citation Impact
0.00
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article

Defining immune-active mechanisms of PDL1V in translational ADC development

Megan Atkins
Bioconjugation Insights
Cancer Immunotherapy and Biomarkers
article

Defining immune-active mechanisms of PDL1V in translational ADC development

Megan Atkins
article en

Abstract

“Our observation of synergistic antitumor activity at multiple nonclinical doses supports that PDL1V allows the functional activation and trafficking of PD-L1-positive cytotoxic immune cells within a wide therapeutic window.”Lauren Coyle (Launch Commissioning Editor, Bioconjugate Insights) speaks with Megan Atkins (Senior Scientist, Translational Pharmacology, Pfizer) about advancing PDL1V from non-clinical characterization to pivotal trials, and how deeper immune profiling is reshaping the future of immune-active ADCs.

Bioconjugation InsightsVol. 1(1)
Pfizer (United States) (US)
Openalex Percentile: Top 83%
Cancer Immunotherapy and Biomarkers
DOISourceOpenAlex
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Defining immune-active mechanisms of PDL1V in translational ADC development — Megan Atkins · Bioconjugation Insights (2026) | TGRS Research Map | TGRS