An unexpected finding of large bowel obstruction from colonic diaphragm disease following prolonged use of indomethacin

Colonic stricture leading to large bowel obstruction is an uncommon presentation to the emergency department. Strictures are commonly established secondary to diverticular disease, inflammatory bowel disease, malignancy or ischaemic/infective colitis. The formation of a colonic stricture secondary to the chronic use of non-steroidal anti-inflammatory drugs (NSAIDs) is an unusual finding. We present a case of a 48-year-old lady who presented with a large bowel obstruction secondary to NSAID-induced right colonic stricture in a patient who was initially thought to have an index presentation of colonic Crohn's disease.

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Publication Details

Journal
Journal of Surgical Case Reports
Published
2025-12-23
DOI
https://doi.org/10.1093/jscr/rjaf1074
Primary Topic
Inflammatory mediators and NSAID effects
Type
article
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article

An unexpected finding of large bowel obstruction from colonic diaphragm disease following prolonged use of indomethacin

Evangeline Woodford, Raymond Kwok, Isabella Zappala, Joseph Do Woong Choi et al.
Journal of Surgical Case Reports
Inflammatory mediators and NSAID effects
article

An unexpected finding of large bowel obstruction from colonic diaphragm disease following prolonged use of indomethacin

Evangeline Woodford, Raymond Kwok, Isabella Zappala, Joseph Do Woong Choi, Peter Dutton
article en

Abstract

Colonic stricture leading to large bowel obstruction is an uncommon presentation to the emergency department. Strictures are commonly established secondary to diverticular disease, inflammatory bowel disease, malignancy or ischaemic/infective colitis. The formation of a colonic stricture secondary to the chronic use of non-steroidal anti-inflammatory drugs (NSAIDs) is an unusual finding. We present a case of a 48-year-old lady who presented with a large bowel obstruction secondary to NSAID-induced right colonic stricture in a patient who was initially thought to have an index presentation of colonic Crohn's disease.

Journal of Surgical Case ReportsVol. 2026(1)
The University of Sydney (AU), Norwood Hospital (US), Westmead Hospital (AU), Cooperative Trials Group for Neuro-Oncology (AU)
Good health and well-being
Openalex Percentile: Top 28%
Inflammatory mediators and NSAID effects
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