Crizotinib in Patients with Tumors with <i>MET</i> Amplification or Exon 14 Deletion: Results from the NCI-MATCH ECOG-ACRIN Trial (EAY131) Subprotocols C1 and C2
Crizotinib demonstrated clinical activity across tumors with METamp and METex14.Subprotocol C1, but not C2, met its primary endpoint. In METex14 disease, a read count cutoff >50,000 may help distinguish true pathogenic variants from low-level splice transcripts and enable more accurate classification.
Authors
- Ju Cheng
- B. Conley
- Alice P. Chen (ORCID: https://orcid.org/0000-0002-2919-4326)
- Chris Karlovich (ORCID: https://orcid.org/0000-0002-4617-2161)
- James A. Zwiebel (ORCID: https://orcid.org/0000-0003-4455-8789)
- David R. Patton (ORCID: https://orcid.org/0000-0003-3855-0166)
- Lisa M. McShane (ORCID: https://orcid.org/0000-0001-8195-3206)
- Carlos L. Arteaga (ORCID: https://orcid.org/0000-0003-0870-9586)
- N. Coleman
- V. Wang
- Jessica Jones Croley
- Stanley R. Hamilton (ORCID: https://orcid.org/0000-0002-8331-1052)
- Zihan Wei (ORCID: https://orcid.org/0000-0003-1734-3643)
- Elad Sharon (ORCID: https://orcid.org/0000-0002-2512-3539)
- Adedayo A. Onitilo (ORCID: https://orcid.org/0000-0001-9185-0606)
- Travis Williams
- James V. Tricoli
- Keith T. Flaherty
- David S. Hong
- A. John Iafrate
- P. Mickey Williams
- Peter J. O'Dwyer
- Naoko Takebe
- Robert J. Gray
- Lyndsay Harris
Institutions
- City Of Hope National Medical Center (US)
- The University of Texas MD Anderson Cancer Center (US)
- Trinity College Dublin (IE)
- Oklahoma City University (US)
- Massachusetts General Hospital (US)
- Saint Joseph Hospital East (US)
- Southwestern Medical Center (US)
- City of Hope (US)
- Marshfield Clinic Weston Center (US)
- Frederick National Laboratory for Cancer Research (US)
- National Cancer Institute (MY)
- National Cancer Institute (US)
- St. Luke's Mountain States Tumor Institute (US)
- St. James's Hospital (IE)
- University of Oklahoma Health Sciences Center (US)
- University of Pennsylvania (US)
- The University of Texas Southwestern Medical Center (US)
- University of Oklahoma (US)
Publication Details
- Journal
- Clinical Cancer Research
- Published
- 2026-01-20
- DOI
- https://doi.org/10.1158/1078-0432.ccr-25-1247
- Primary Topic
- Lung Cancer Treatments and Mutations
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- American College of Radiology Imaging Network
- Margaret A. Cargill Foundation
- ECOG-ACRIN Cancer Research Group
- National Institutes of Health
- National Cancer Institute