Pencil beam scanning proton lattice radiotherapy: single-field versus multi-field optimization

Both SFO and MFO techniques can be reliably implemented with current proton beam quality standards and advanced treatment planning algorithms. While SFO offers better plan robustness in maintaining the originally optimized metrics under various treatment-related uncertainties, MFO enhances the ability to spare critical organs.

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Publication Details

Journal
Frontiers in Oncology
Published
2026-01-20
DOI
https://doi.org/10.3389/fonc.2025.1716722
Primary Topic
Radiation Therapy and Dosimetry
Type
article
Field-Weighted Citation Impact
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article

Pencil beam scanning proton lattice radiotherapy: single-field versus multi-field optimization

C. Guha, K. Alektiar, Annemarie Fernandes Shepherd, Haibo Lin et al.
Frontiers in Oncology
Radiation Therapy and Dosimetry
article

Pencil beam scanning proton lattice radiotherapy: single-field versus multi-field optimization

C. Guha, K. Alektiar, Annemarie Fernandes Shepherd, Haibo Lin, Hang Qi, Lee Xu, Ajay Zheng, Pingfang Tsai, Irini Yacoub, Xiaodong Wu, Shouyi Wei, Charles B. Simone, Arpit Chhabra, Richard Bakst, Minglei Kang, Nancy Y. Lee, Milo Vermeulen
article en

Abstract

Both SFO and MFO techniques can be reliably implemented with current proton beam quality standards and advanced treatment planning algorithms. While SFO offers better plan robustness in maintaining the originally optimized metrics under various treatment-related uncertainties, MFO enhances the ability to spare critical organs.

Frontiers in OncologyVol. 15
Albert Einstein College of Medicine (US), Memorial Sloan Kettering Cancer Center (US), University of Wisconsin–Madison (US), New York Proton Center (US), Medical Research Associates (US), Icahn School of Medicine at Mount Sinai (US)
Openalex Percentile: Top 84%
Radiation Therapy and Dosimetry
DOIOpen Access PDFOpenAlex
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Pencil beam scanning proton lattice radiotherapy: single-field versus multi-field optimization — C. Guha, K. Alektiar, et al. · Frontiers in Oncology (2026) | TGRS Research Map | TGRS