5-methylcytosine and 5-hydroxymethylcytosine are synergistic biomarkers for early detection of colorectal cancer
These results support the hypothesis that distinguishing between 5mC and 5hmC improves the sensitivity of liquid biopsy tests for early-stage cancer detection.
Authors
- Casper K. Lumby (ORCID: https://orcid.org/0000-0001-8329-9228)
- Tom Charlesworth (ORCID: https://orcid.org/0000-0001-9233-7679)
- Riccha Sethi (ORCID: https://orcid.org/0000-0003-2948-9711)
- Jean Teyssandier (ORCID: https://orcid.org/0000-0002-6277-2933)
- Fabio Puddu (ORCID: https://orcid.org/0000-0002-2033-5209)
- Robert J. Osborne (ORCID: https://orcid.org/0000-0002-1914-1239)
- Aurélie Modat
- Jamie Scotcher
- Mark D. Hill
- Shankar Balasubramanian
- Robert Crawford
- Nick Harding
- Shirong Yu
- Annelie Johansson
- Michael Wilson
- Páidí Creed
Institutions
- Princeton University (US)
- University of Cambridge (GB)
- Cancer Research UK (GB)
- Building Research Institute (JP)
- Trinity House (GB)
Publication Details
- Journal
- Communications Medicine
- Published
- 2026-01-20
- DOI
- https://doi.org/10.1038/s43856-025-01278-8
- Primary Topic
- Epigenetics and DNA Methylation
- Type
- article
- Field-Weighted Citation Impact
- 0.00