Senolytics, dasatanib plus quercetin, reduce kidney inflammation, senescent cell abundance, and injury while restoring geroprotective factors in murine diabetic kidney disease
This research was supported by National Institutes of Health (NIH): [DK123492, DK109134, and AG076537 (LJH); DK120292 and HL158691 (LOL); AG087387 (YZ); R37AG013925 (TT and JLK)]; NIDDK Diabetes Complications Consortium [DK115255, DK076169 (LJH)]; Mayo Clinic Robert D. and Patricia E. Kern Center for the Science of Health Care Delivery (LJH); TT and JLK are supported by a grant from the Hevolution Foundation (HF-GRO-23-1199148-3), Cedars-Sinai Medical Center, the Connor Fund, and Robert J. and Theresa W. Ryan.
Authors
- Zachary K. Snow
- LaTonya J. Hickson (ORCID: https://orcid.org/0000-0002-7485-336X)
- S KHOSLA
- C. Zinn
- Khaled Elhusseiny (ORCID: https://orcid.org/0000-0002-2230-2160)
- Seo Rin Kim (ORCID: https://orcid.org/0000-0003-3552-0519)
- Anastasia L. Bratulin (ORCID: https://orcid.org/0000-0001-9263-0891)
- Tamar Tchkonia
- James L. Kirkland
- Xiaohui Bian
- Yi Zhu
- Lilach O. Lerman
Institutions
- Cedars-Sinai Medical Center (US)
- Mayo Clinic (US)
- The University of Texas at San Antonio Health Science Center (US)
- Jacksonville College (US)
- Mayo Clinic in Arizona (US)
- Mayo Clinic in Florida (US)
- Pusan National University (KR)
- China Medical University (CN)
Publication Details
- Journal
- EBioMedicine
- Published
- 2026-01-20
- DOI
- https://doi.org/10.1016/j.ebiom.2026.106124
- Citations
- 1
- Primary Topic
- Telomeres, Telomerase, and Senescence
- Type
- article
- Field-Weighted Citation Impact
- 32.84