Intermittent fasting reduces glaucomatous damage in an HSP27 autoimmune mouse model

Intravitreal injection of HSP27 resulted in RGC loss and was associated with gliosis. In contrast, intermittent fasting conferred neuroprotective effects, likely by modulating neuroinflammatory pathways, and hence protected RGCs from damage. These findings highlight intermittent fasting as a potential adjunctive therapeutic strategy for glaucoma management.