Virus-Specific T Cells and Response to Checkpoint Inhibitors in Progressive Multifocal Leukoencephalopathy

Preexisting functional virus-specific T cells were associated with better clinical response, longer survival, and lower toxicity in PML. These findings suggest the likely importance of preexisting antiviral immunity for successful ICI therapy.

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Publication Details

Journal
JAMA Neurology
Published
2026-01-20
DOI
https://doi.org/10.1001/jamaneurol.2025.5318
Primary Topic
Polyomavirus and related diseases
Type
article
Field-Weighted Citation Impact
0.00

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article

Virus-Specific T Cells and Response to Checkpoint Inhibitors in Progressive Multifocal Leukoencephalopathy

P. Duffau, Eleonora Cimini, Rebecca Wicklein, Sharmilee Gnanapavan et al.
JAMA Neurology
Polyomavirus and related diseases
article

Virus-Specific T Cells and Response to Checkpoint Inhibitors in Progressive Multifocal Leukoencephalopathy

P. Duffau, Eleonora Cimini, Rebecca Wicklein, Sharmilee Gnanapavan, Xavier Engalenc, Dr Jonathan Ciron, Marcel Hildner, Sandra Nay, Asaff Harel, T. Skripuletz, F. Gourdon, Y. Leveneur, Laurence Hellouin de Menibus, Louisa Nitsch, Clemens Küpper, C Kleinschnitz, Christoph Helmchen, Yael Dinur-Schejter, Baptiste Bonneau, Ruth Schneider, Douglas Ney, Marine Joly, R. Lajaunie, Britta Maecker‐Kolhoff, Emmanuel Treiner, Arnaud Del Bello, Franz Felix Konen, Agnès Sommet, Achille Eric Aouba, Konstantin Fritz Jendretzky, Sabine Tischer-Zimmermann, Martijn T. Wijburg, Marion Gaudin, Agnes Bonifacius, Ilijas jelČiĆ, Ronak K. Kapadia, Laura Alt, Ilya Ayzenberg, Kevin Karacondi, Jacques Gasnault, Nicolas Lambert, Sara Zahraeifard, Stephan Klebe, Fleur Cohen-Aubart, Nassim Kamar, Victoria Manda, Sebastian Rauer, Andrea Antinori, Oliver M Grauer, Sebastian Böltz, Petra Hühnchen, Raphael Bernard-Valnet, Britta Eiz-Vesper, Refik Pul, Christian Grefkes, Martijn Beudel, Kurt-Wolfram Sühs, Niklas Grassl, Damien Biotti, Marc Pawlitzki, Yasemin Goreci, Xavier Brousse, Bodo Grimbacher, Immunotherapy for PML Study Group, Fabrice Bonneville, Matthijs Brouwer, Pierre Delobel, Mailys Ducours, Norbert Brüggemann, David Clifford, Carole Ribaute, Tzlil Shifman, Clemens Warnke, Guillaume Martin-Blondel, Benjamin Wyplosz, Sven G. Meuth, Francois Lifermann, Joseph Berger, Carmela Pinnetti, Béatrice Pignolet, Olivier Lambotte, Irene Cortese, Mieke Luise Sassmann, Lea Martha Grote-Levi, Valérie Pourcher, Hela Mrabet, Hayrettin Tumani, Oded Shamriz, Juliette Rakotoarison Rakotoarison, Xavier Boumaza, Marion Le Maréchal, Nora Möhn, Melanie Zent, Jean Christophe Ouallet, Heinz Wiendl
article en

Abstract

Preexisting functional virus-specific T cells were associated with better clinical response, longer survival, and lower toxicity in PML. These findings suggest the likely importance of preexisting antiviral immunity for successful ICI therapy.

JAMA NeurologyVol. 83(3)
Goethe University Frankfurt (DE), Centre National de la Recherche Scientifique (FR), Inserm (FR), University of Freiburg (DE), Philipps University of Marburg (DE), Queen Mary University of London (GB), Université Fédérale de Toulouse Midi-Pyrénées (FR), Friedrich-Alexander-Universität Erlangen-Nürnberg (DE), University of Zurich (CH), Washington University in St. Louis (US), Barts Health NHS Trust (GB), Universitätsklinikum Gießen und Marburg (DE), University Hospital Bonn (DE), University Medical Center Freiburg (DE), German Center for Neurodegenerative Diseases (DE), LMU Klinikum (DE), Medizinische Hochschule Hannover (DE), Humboldt-Universität zu Berlin (DE), Sorbonne Université (FR), Universitätsklinikum Erlangen (DE), Düsseldorf University Hospital (DE), Istituto Nazionale per le Malattie Infettive Lazzaro Spallanzani (IT), Toulouse Mathematics Institute (FR), University Hospital of Zurich (CH), Hospices Civils de Lyon (FR), University Hospital Münster (DE), Parker Institute for Cancer Immunotherapy (US), National Institute of Neurological Disorders and Stroke (US), University Hospital Schleswig-Holstein (DE), Munich Cluster for Systems Neurology (DE), Essen University Hospital (DE), Pitié-Salpêtrière Hospital (FR), Hôpital Rangueil (FR), University Hospital Frankfurt (DE), St. Josef-Hospital (DE), Amsterdam University Medical Centers (NL), University Hospital Ulm (DE), Centre hospitalier régional de la Citadelle (BE), Bicêtre Hospital (FR), Heinrich Heine University Düsseldorf (DE), Technical University of Munich (DE), Freie Universität Berlin (DE), Charité - Universitätsmedizin Berlin (DE), Ludwig-Maximilians-Universität München (DE), University of Amsterdam (NL), Ruhr University Bochum (DE), University of Lübeck (DE)
Institut National de la Santé et de la Recherche Médicale, Albert-Ludwigs-Universität Freiburg, Université de Toulouse, Centre National de la Recherche Scientifique, Deutsches Zentrum für Neurodegenerative Erkrankungen, Medizinischen Hochschule Hannover, Universität Zürich, Centre Hospitalier Universitaire de Toulouse, Universitätsspital Zürich, Assistance publique-Hôpitaux de Paris, Sorbonne Université
Openalex Percentile: Top 83%
Polyomavirus and related diseases
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