Virus-Specific T Cells and Response to Checkpoint Inhibitors in Progressive Multifocal Leukoencephalopathy
Preexisting functional virus-specific T cells were associated with better clinical response, longer survival, and lower toxicity in PML. These findings suggest the likely importance of preexisting antiviral immunity for successful ICI therapy.
Authors
- P. Duffau (ORCID: https://orcid.org/0000-0002-4463-6583)
- Eleonora Cimini
- Rebecca Wicklein (ORCID: https://orcid.org/0000-0002-6661-6081)
- Sharmilee Gnanapavan (ORCID: https://orcid.org/0000-0003-2817-9922)
- Xavier Engalenc
- Dr Jonathan Ciron
- Marcel Hildner
- Sandra Nay (ORCID: https://orcid.org/0000-0002-4986-1181)
- Asaff Harel
- T. Skripuletz
- F. Gourdon
- Y. Leveneur
- Laurence Hellouin de Menibus
- Louisa Nitsch (ORCID: https://orcid.org/0000-0002-5139-6848)
- Clemens Küpper (ORCID: https://orcid.org/0000-0002-1507-8033)
- C Kleinschnitz
- Christoph Helmchen (ORCID: https://orcid.org/0000-0003-2493-2294)
- Yael Dinur-Schejter (ORCID: https://orcid.org/0000-0003-3332-2391)
- Baptiste Bonneau
- Ruth Schneider (ORCID: https://orcid.org/0000-0002-0997-2725)
- Douglas Ney (ORCID: https://orcid.org/0000-0001-7273-8141)
- Marine Joly (ORCID: https://orcid.org/0000-0002-0191-2584)
- R. Lajaunie (ORCID: https://orcid.org/0000-0003-1570-9429)
- Britta Maecker‐Kolhoff (ORCID: https://orcid.org/0000-0001-8164-514X)
- Emmanuel Treiner (ORCID: https://orcid.org/0000-0001-6249-4534)
- Arnaud Del Bello (ORCID: https://orcid.org/0000-0003-3115-868X)
- Franz Felix Konen (ORCID: https://orcid.org/0000-0002-8609-5674)
- Agnès Sommet (ORCID: https://orcid.org/0000-0001-7980-5650)
- Achille Eric Aouba
- Konstantin Fritz Jendretzky
- Sabine Tischer-Zimmermann (ORCID: https://orcid.org/0000-0003-2326-0342)
- Martijn T. Wijburg (ORCID: https://orcid.org/0000-0002-0490-5638)
- Marion Gaudin
- Agnes Bonifacius (ORCID: https://orcid.org/0000-0002-0112-967X)
- Ilijas jelČiĆ
- Ronak K. Kapadia (ORCID: https://orcid.org/0000-0002-9820-0486)
- Laura Alt
- Ilya Ayzenberg (ORCID: https://orcid.org/0009-0007-9491-2180)
- Kevin Karacondi
- Jacques Gasnault
- Nicolas Lambert
- Sara Zahraeifard
- Stephan Klebe
- Fleur Cohen-Aubart
- Nassim Kamar
- Victoria Manda (ORCID: https://orcid.org/0009-0003-9328-9535)
- Sebastian Rauer (ORCID: https://orcid.org/0000-0002-9889-078X)
- Andrea Antinori
- Oliver M Grauer
- Sebastian Böltz
- Petra Hühnchen
- Raphael Bernard-Valnet
- Britta Eiz-Vesper
- Refik Pul
- Christian Grefkes
- Martijn Beudel
- Kurt-Wolfram Sühs
- Niklas Grassl
- Damien Biotti
- Marc Pawlitzki
- Yasemin Goreci
- Xavier Brousse
- Bodo Grimbacher
- Immunotherapy for PML Study Group
- Fabrice Bonneville
- Matthijs Brouwer
- Pierre Delobel
- Mailys Ducours
- Norbert Brüggemann
- David Clifford
- Carole Ribaute
- Tzlil Shifman
- Clemens Warnke
- Guillaume Martin-Blondel
- Benjamin Wyplosz
- Sven G. Meuth
- Francois Lifermann
- Joseph Berger
- Carmela Pinnetti
- Béatrice Pignolet
- Olivier Lambotte
- Irene Cortese
- Mieke Luise Sassmann
- Lea Martha Grote-Levi
- Valérie Pourcher
- Hela Mrabet
- Hayrettin Tumani
- Oded Shamriz
- Juliette Rakotoarison Rakotoarison
- Xavier Boumaza
- Marion Le Maréchal
- Nora Möhn
- Melanie Zent
- Jean Christophe Ouallet
- Heinz Wiendl
Institutions
- Goethe University Frankfurt (DE)
- Centre National de la Recherche Scientifique (FR)
- Inserm (FR)
- University of Freiburg (DE)
- Philipps University of Marburg (DE)
- Queen Mary University of London (GB)
- Université Fédérale de Toulouse Midi-Pyrénées (FR)
- Friedrich-Alexander-Universität Erlangen-Nürnberg (DE)
- University of Zurich (CH)
- Washington University in St. Louis (US)
- Barts Health NHS Trust (GB)
- Universitätsklinikum Gießen und Marburg (DE)
- University Hospital Bonn (DE)
- University Medical Center Freiburg (DE)
- German Center for Neurodegenerative Diseases (DE)
- LMU Klinikum (DE)
- Medizinische Hochschule Hannover (DE)
- Humboldt-Universität zu Berlin (DE)
- Sorbonne Université (FR)
- Universitätsklinikum Erlangen (DE)
- Düsseldorf University Hospital (DE)
- Istituto Nazionale per le Malattie Infettive Lazzaro Spallanzani (IT)
- Toulouse Mathematics Institute (FR)
- University Hospital of Zurich (CH)
- Hospices Civils de Lyon (FR)
- University Hospital Münster (DE)
- Parker Institute for Cancer Immunotherapy (US)
- National Institute of Neurological Disorders and Stroke (US)
- University Hospital Schleswig-Holstein (DE)
- Munich Cluster for Systems Neurology (DE)
- Essen University Hospital (DE)
- Pitié-Salpêtrière Hospital (FR)
- Hôpital Rangueil (FR)
- University Hospital Frankfurt (DE)
- St. Josef-Hospital (DE)
- Amsterdam University Medical Centers (NL)
- University Hospital Ulm (DE)
- Centre hospitalier régional de la Citadelle (BE)
- Bicêtre Hospital (FR)
- Heinrich Heine University Düsseldorf (DE)
- Technical University of Munich (DE)
- Freie Universität Berlin (DE)
- Charité - Universitätsmedizin Berlin (DE)
- Ludwig-Maximilians-Universität München (DE)
- University of Amsterdam (NL)
- Ruhr University Bochum (DE)
- University of Lübeck (DE)
Publication Details
- Journal
- JAMA Neurology
- Published
- 2026-01-20
- DOI
- https://doi.org/10.1001/jamaneurol.2025.5318
- Primary Topic
- Polyomavirus and related diseases
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Institut National de la Santé et de la Recherche Médicale
- Albert-Ludwigs-Universität Freiburg
- Université de Toulouse
- Centre National de la Recherche Scientifique
- Deutsches Zentrum für Neurodegenerative Erkrankungen
- Medizinischen Hochschule Hannover
- Universität Zürich
- Centre Hospitalier Universitaire de Toulouse
- Universitätsspital Zürich
- Assistance publique-Hôpitaux de Paris
- Sorbonne Université