From inflammation to degeneration: role of MMPs, IL6, and TIMP-1 in systemic sclerosis and aortic dissection
Mice with SSc were more prone to aortic dissection, potentially due to enhanced MMP activity in the aortic wall, underlining the importance of MMPs in the pathogenesis of aortic dissection in connective tissue diseases and indicating a pathway for future therapeutic interventions by targeting MMPs to mitigate the risk of aortic dissection in patients with SSc.
Authors
- Jiafang Wu
- H Z Lu
- L N Yang
Institutions
- Inner Mongolia University of Science and Technology (CN)
- Baotou Central Hospital (CN)
- Baotou Medical College (CN)
- Inner Mongolia Medical University (CN)
Publication Details
- Journal
- Acta cardiologica. Supplementum
- Published
- 2026-01-20
- DOI
- https://doi.org/10.1080/00015385.2025.2597115
- Primary Topic
- Aortic Disease and Treatment Approaches
- Type
- article
- Field-Weighted Citation Impact
- 0.00