A Comparison of Cigarette Smoking Effects on Intervertebral Disc Cell Metabolism in a Rat Tissue Model
Cigarette smoking impairs IVD cellular energy metabolism through both direct toxic exposure and indirect nutrient deprivation mechanisms, with the modeled low-nutrient conditions having a more pronounced effect. The NP is the most metabolically sensitive region in the IVD, while the CEP is more resilient to fluctuations with its environment. These findings provide insights into IVD metabolic adaptations to smoking.
Authors
- Danyelle M. Townsend (ORCID: https://orcid.org/0000-0003-4679-1891)
- Avery Madden
- Nathan Buchweitz
- Yongren Wu (ORCID: https://orcid.org/0000-0002-5411-8528)
- Hui Li
- Michael Kern
- Hai Yao
- Zhaoxu Meng
- Joshua Kelley
Institutions
- Medical University of South Carolina (US)
- Clemson University (US)
Publication Details
- Journal
- Annals of Biomedical Engineering
- Published
- 2026-01-20
- DOI
- https://doi.org/10.1007/s10439-025-03958-x
- Primary Topic
- Spine and Intervertebral Disc Pathology
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Cervical Spine Research Society
- University of South Carolina
- National Institutes of Health
- National Institute of General Medical Sciences
- National Institute of Dental and Craniofacial Research