ANA-12 restores testicular health by local neurochemicals in passive smoking/nicotine-exposed preclinical adult rats
The results offer a novel insight into therapeutic interventions for passive or secondhand smoking- or environmental tobacco smoke-induced male reproductive impairment via regulation of BDNF-dopaminergic signaling and antioxidant balance in testes by ANA-12, leading to improved fertility potential and overall testicular health, which could establish the modulation of the brain-testes axis, implicated in nicotine addiction. This study holds translational potential of ANA-12 for the management of smoking- or nicotine-related male infertility of individuals unable or unwilling to quit smoking.
Authors
- Vishakha Shrimali (ORCID: https://orcid.org/0000-0003-0778-0209)
- Vijay Shivgotra (ORCID: https://orcid.org/0000-0003-2554-5587)
- Deepsi Rathore (ORCID: https://orcid.org/0000-0001-7467-5455)
- Nibedita Naha
Institutions
- University of Jammu (IN)
- National Institute of Occupational Health (IN)
Publication Details
- Journal
- F&S Science
- Published
- 2026-01-19
- DOI
- https://doi.org/10.1016/j.xfss.2025.11.003
- Primary Topic
- Sperm and Testicular Function
- Type
- article
- Field-Weighted Citation Impact
- 0.00