RUNX1 N6-methyladenosine methylation enhances cytoskeleton remodelling and boosts cardiac fibrosis
Our study reveals a novel epitranscriptomic pathway wherein YTHDF1 recognizes m6A-modified Runx1 mRNA, enhancing its translation and thereby stimulating RUNX1-mediated Ctgf transcription. This process drives cytoskeletal remodelling, cardiac fibroblast proliferation, and fibrosis in an m6A-dependent manner. These findings offer new perspectives for developing preventive strategies against cardiac fibrosis.
Authors
- Sui Mao
- Ji-Fei Ding
- W. T. Liu (ORCID: https://orcid.org/0000-0002-0917-6729)
- Lei Gao (ORCID: https://orcid.org/0000-0002-1832-018X)
- Bin Tu
- Jingjing Yang (ORCID: https://orcid.org/0000-0003-4434-9995)
- Biao Xu (ORCID: https://orcid.org/0000-0003-1095-8901)
- Jianyuan Zhao
- Haoran Geng (ORCID: https://orcid.org/0000-0001-5115-4446)
- Zhenyu Liu
- Hui Tao
- Li-Chan Lin
Institutions
- Nanjing University of Chinese Medicine (CN)
- Shanghai Jiao Tong University (CN)
- Anhui Medical University (CN)
- XinHua Hospital (CN)
- Second Affiliated Hospital of Anhui Medical University (CN)
Publication Details
- Journal
- Cardiovascular Research
- Published
- 2026-01-15
- DOI
- https://doi.org/10.1093/cvr/cvag010
- Primary Topic
- RNA modifications and cancer
- Type
- article
- Field-Weighted Citation Impact
- 0.00