Liver Safety Assessment of an Indonesian Hexavalent Vaccine Candidate Through Histopathology and ALT/AST Evaluation in Rats and Rabbits
Repeated administration of the hexavalent vaccine candidate at low and high doses produced no toxicological effects in animal models, supporting its safety for further clinical development.
Authors
- Reviany V. Nidom (ORCID: https://orcid.org/0000-0003-1433-6026)
- Arif Rahman Sadjuri (ORCID: https://orcid.org/0009-0001-8077-2515)
- Acep R. Wijayadikusumah (ORCID: https://orcid.org/0000-0003-1104-9259)
- Hani Plumeriastuti
- Arip Hidayat (ORCID: https://orcid.org/0000-0001-8427-2617)
- Setyarina Indrasari (ORCID: https://orcid.org/0000-0002-3685-6981)
- Chairul A. Nidom (ORCID: https://orcid.org/0000-0002-8106-0763)
- Tiza W. Mawaddah
- Kuncoro P. Santoso
- Zakiyyan I. Ayyuba
- Soeharsono
- Dimas T. Nugroho
- Astria N. Nidom
- Eka S. Wahyuningsih
- Elisa D. Pratiwi
Institutions
- Universitas Airlangga (ID)
- Institut Teknologi Nasional Malang (ID)
- PT Bio Farma (Indonesia) (ID)
Publication Details
- Journal
- Vaccines
- Published
- 2026-01-19
- DOI
- https://doi.org/10.3390/vaccines14010094
- Primary Topic
- Diphtheria, Corynebacterium, and Tetanus
- Type
- article
- Field-Weighted Citation Impact
- 0.00