Combined Anti-CD20/Anti-CD38 Therapy in Posttransplant Focal Segmental Glomerulosclerosis Recurrence: A Retrospective, International, Multicenter Study
Despite the retrospective, nonrandomized design, the temporal association between treatment and remission supports an effect of anti-CD38 monoclonal antibody alone or in combination with anti-CD20. Treatment is safe and may confer enhanced efficacy over standard approaches. Prospective, mechanistic studies are warranted to validate these findings and delineate the immunopathogenesis of FSGS recurrence.
Authors
- Xhuliana Kajana (ORCID: https://orcid.org/0000-0001-7016-7584)
- Alessandra Palmisano
- Andrea Angeletti (ORCID: https://orcid.org/0000-0002-6121-5326)
- Ali Poyan Mehr (ORCID: https://orcid.org/0000-0001-5610-2979)
- Nelson Goes (ORCID: https://orcid.org/0000-0002-3129-254X)
- F. Vincenti
- Micaela Gentile
- Gian Marco Ghiggeri (ORCID: https://orcid.org/0000-0003-3659-9062)
- Gianluca Caridi (ORCID: https://orcid.org/0000-0001-6700-3001)
- Gabriele Mortari (ORCID: https://orcid.org/0009-0002-7113-6258)
- Paolo Cravedi
- Alberto Magnasco (ORCID: https://orcid.org/0000-0002-1431-4794)
- Nicola Bossini
- Rohan V. Mehta
- Agnese Spennacchio
- Giorgia Comai
- Carolina Bigatti
- Nicolas Bouvier
- Frank E. Hullekes
- Enrico E. Verrina
- Gaetano La Manna
- Simona Barbuto
- Umberto Maggiore
- Leonardo V. Riella
Institutions
- University of Parma (IT)
- Harvard University (US)
- Illinois College (US)
- University of California, San Francisco (US)
- Istituto Giannina Gaslini (IT)
- University of Florida (US)
- University of Illinois Chicago (US)
- Massachusetts General Hospital (US)
- Azienda Socio Sanitaria Territoriale degli Spedali Civili di Brescia (IT)
- Azienda USL di Bologna (IT)
- Kaiser Permanente San Francisco Medical Center (US)
- Azienda Socio Sanitaria Territoriale Lariana (IT)
- Istituti di Ricovero e Cura a Carattere Scientifico (IT)
- University of Brescia (IT)
- University of Bologna (IT)
- Université de Caen Normandie (FR)
- Icahn School of Medicine at Mount Sinai (US)
Publication Details
- Journal
- Transplantation Direct
- Published
- 2026-01-20
- DOI
- https://doi.org/10.1097/txd.0000000000001908
- Primary Topic
- Renal Diseases and Glomerulopathies
- Type
- article
- Field-Weighted Citation Impact
- 0.00