Genetic dissection of stool frequency implicates vitamin B1 metabolism and other actionable pathways in the modulation of gut motility
We identify therapeutically tractable mechanisms involved in the control of gut motility, including a previously unrecognised role for vitamin B1. These findings warrant mechanistic and clinical studies to evaluate their translational potential in IBS and other dysmotility syndromes.
Authors
- Cristina Esteban Blanco
- Ferdinando Bonfiglio (ORCID: https://orcid.org/0000-0003-2488-3867)
- A. Zhernakova
- Esteban Alexander Lopera-Maya
- Letícia Camargo Tavares (ORCID: https://orcid.org/0000-0001-7278-0999)
- Cristian Díaz-Muñoz
- Valeria Lo Faro
- Philip Awadalla
- Trishla Sinha
- Biagio Di Lorenzo
- Serena Sanna
- Lazaros Belbasis
- Mauro D’Amato
- Francisco Heredia-Fernández
- Isotta Bozzarelli
Institutions
- Ikerbasque (ES)
- Ontario Institute for Cancer Research (CA)
- Libera Università Maria SS. Assunta (IT)
- University Medical Center Groningen (NL)
- University of Groningen (NL)
- University of Oxford (GB)
- CIC bioGUNE (ES)
- Institute of Genetic and Biomedical Research (IT)
- CEINGE Biotecnologie Avanzate Franco Salvatore (Italy) (IT)
- Australian Centre for Heart Health (AU)
- National Research Council (IT)
- Concordia University (CA)
- University of Naples Federico II (IT)
Publication Details
- Journal
- Gut
- Published
- 2026-01-20
- DOI
- https://doi.org/10.1136/gutjnl-2025-337059
- Primary Topic
- Gastrointestinal motility and disorders
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Nederlandse Organisatie voor Wetenschappelijk Onderzoek
- Universitair Medisch Centrum Groningen
- European Regional Development Fund