No Evidence of Microsatellite Instability in Head and Neck Squamous Cell Carcinoma of Non‐Smokers and Non‐Drinkers

This study shows no single case with MSI in the NSND subgroup of HNSCC. Although a deficient DNA mismatch repair system is a predictive biomarker for response to immune checkpoint inhibitors, we found no evidence to support routine analysis of MSI in HNSCC, also not in the subgroup of NSND.

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Publication Details

Journal
Journal of Oral Pathology and Medicine
Published
2026-01-19
DOI
https://doi.org/10.1111/jop.70120
Primary Topic
Genetic factors in colorectal cancer
Type
article
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article

No Evidence of Microsatellite Instability in Head and Neck Squamous Cell Carcinoma of Non‐Smokers and Non‐Drinkers

F. J. Mulder, S. M. Willems, R. de Bree, T. F. B. Gielgens et al.
Journal of Oral Pathology and Medicine
Genetic factors in colorectal cancer
article

No Evidence of Microsatellite Instability in Head and Neck Squamous Cell Carcinoma of Non‐Smokers and Non‐Drinkers

F. J. Mulder, S. M. Willems, R. de Bree, T. F. B. Gielgens, E. J. de Ruiter, E. J. M. Speel, B. Kremer, M. F. C. M. van den Hout
article en

Abstract

This study shows no single case with MSI in the NSND subgroup of HNSCC. Although a deficient DNA mismatch repair system is a predictive biomarker for response to immune checkpoint inhibitors, we found no evidence to support routine analysis of MSI in HNSCC, also not in the subgroup of NSND.

Journal of Oral Pathology and Medicine
University Medical Center Groningen (NL), Maastricht University Medical Centre (NL), Erasmus MC (NL), University Medical Center Utrecht (NL), Maastricht University (NL), Amsterdam University Medical Centers (NL), Maastro Clinic (NL), University of Amsterdam (NL), Erasmus University Rotterdam (NL)
Good health and well-being
Openalex Percentile: Top 84%
Genetic factors in colorectal cancer
DOIOpen Access PDFOpenAlex
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No Evidence of Microsatellite Instability in Head and Neck Squamous Cell Carcinoma of Non‐Smokers and Non‐Drinkers — F. J. Mulder, S. M. Willems, et al. · Journal of Oral Pathology and Medicine (2026) | TGRS Research Map | TGRS