Elevated Asporin expression in human atherosclerotic plaques promotes their stability and reduces the risk for cardiovascular events
ASPN is a regulator of vascular calcification in atherosclerosis, promoting a plaque phenotype that is less prone to rupture. Additionally, high ASPN levels are associated with fewer future cardiovascular events.
Authors
- Andreas Edsfeldt (ORCID: https://orcid.org/0000-0002-2691-9192)
- M. Elizabeth Davies (ORCID: https://orcid.org/0000-0002-9446-3924)
- Eva Bengtsson (ORCID: https://orcid.org/0000-0001-7075-1772)
- Annelie Shami (ORCID: https://orcid.org/0000-0002-6976-4397)
- Dianne Acoba (ORCID: https://orcid.org/0000-0001-9760-9178)
- Panagiotis N. Fountas (ORCID: https://orcid.org/0000-0002-7298-2328)
- Jiangming Sun (ORCID: https://orcid.org/0000-0001-6814-1297)
- Chrysostomi Gialeli (ORCID: https://orcid.org/0000-0003-4290-9610)
- Luke F. Gamon (ORCID: https://orcid.org/0000-0001-7894-8035)
- Mihaela Nitulescu
- Ana Persson
- Claudia Goettsch
- Isabel Gonçalves
- Nicoline W Thorsen
Institutions
- University of Copenhagen (DK)
- Malmö University (SE)
- Lund University (SE)
- Wallenberg Wood Science Center (SE)
- Skåne University Hospital (SE)
- BioSurfaces (United States) (US)
- University Hospital Carl Gustav Carus (DE)
- RWTH Aachen University (DE)
Publication Details
- Journal
- Cardiovascular Research
- Published
- 2026-01-15
- DOI
- https://doi.org/10.1093/cvr/cvag015
- Primary Topic
- Proteoglycans and glycosaminoglycans research
- Type
- article
- Field-Weighted Citation Impact
- 0.00