Population pharmacokinetics of isoniazid in adult Indian tuberculosis patients: Evaluation of NAT2 polymorphisms
Our NAT2 genotype-integrated PopPK model, developed for adult Indian tuberculosis patients, revealed distinct differences in isoniazid clearance across NAT2 phenotypes; however, these differences were not statistically significant. NAT2 slow acetylators exhibited more than two-fold lower clearance compared to NAT2 rapid acetylators. These findings highlight the potential importance of NAT2 genotype-guided individualized isoniazid dosing strategies in clinical settings.
Authors
- Levin Thomas (ORCID: https://orcid.org/0000-0003-1520-9598)
- T. Keshava Prasad
- Sakshi Sanjay Parate (ORCID: https://orcid.org/0000-0001-8604-6525)
- JAYA SHREE DILLI BATCHA (ORCID: https://orcid.org/0000-0002-8687-0183)
- M Naveen Varma (ORCID: https://orcid.org/0000-0002-2520-7249)
- Kavitha Saravu
- Mahadev Rao
- Surulivelrajan Mallayasamy
- Shubham Upadhyay
- S.V. Chidananda Sanju
- Chaithra
Institutions
- Yenepoya University (IN)
- Manipal Academy of Higher Education (IN)
- New Delhi Tuberculosis Center (IN)
Publication Details
- Journal
- Infection Genetics and Evolution
- Published
- 2026-01-20
- DOI
- https://doi.org/10.1016/j.meegid.2026.105883
- Primary Topic
- Carcinogens and Genotoxicity Assessment
- Type
- article
- Field-Weighted Citation Impact
- 0.00