Therapeutic Potential of Banana Pseudo- Stem Extracts: A Systematic Review and Meta-Analysis of Antioxidant, Anti- Inflammatory, Antimicrobial, and Anti- Urolithiatic Properties with Risk of Bias Assessment

Banana pseudo-stem, a farming waste, may contain bioactive compounds with therapeutic properties. Due to its antioxidant, anti-inflammatory, antibacterial, and anti-urolithiatic properties, banana pseudo-stem extracts may help manage chronic diseases, infections, and kidney stones, according to recent research A complete synthesis of research must evaluate banana pseudo-stem extract efficacy and safety. Objectives: This systematic review and meta-analysis analyse banana pseudo-stem extracts' antioxidant, anti-inflammatory, antibacterial, and anti-urolithiatic properties. A risk of bias evaluation will evaluate the evidence's quality and reliability. Method: PubMed, Scopus, and Web of Science for banana pseudo-stem extract medical studies. Randomised controlled trials, cohort studies, case-control studies, and preclinical animal studies qualify. Two independent reviewers will examine publications, extract data, and assess bias using the Cochrane Risk of Bias tool for RCTs and the Newcastle-Ottawa Scale for observational studies. Pooled effect sizes will be derived from quantitative data using random-effects meta-analysis. Subgroup analyses will use extraction, dosage, and study population. We will use the I² statistic to quantify heterogeneity and conduct sensitivity experiments as appropriate. Result: Antioxidant capacity, inflammatory marker lowering, antibacterial capabilities, and anti-urolithiatic potential (e.g., urinary oxalate and crystal count) are key outcomes. Secondary outcomes of banana pseudo-stem extract treatment include safety, adverse events, and quality of life. Conclusion: This review will synthesise banana pseudo-stem extracts' therapeutic effects for future study and clinical use. Research will promote banana pseudo-stem as a plant-based therapy and identify gaps. Keywords: Banana pseudo-stem, Therapeutic potential, Antioxidant activity, Anti-inflammatory effects, Antimicrobial properties, Anti-urolithiatic effects, Bioactive compounds, Herbal medicine, Chronic disease management, Sustainable healthcare, Traditional remedies