Unraveling the potential mechanisms of Xiaochaihu decoction alleviates metabolic associated fatty liver disease (MAFLD) by integrated transcriptomics, metabolomics, and network pharmacology
XCHD alleviates MAFLD by decreasing lysophospholipid, regulating liver lipid droplets formation, and targeting PLIN2/PLIN3. PPARγ was one of the cross in for PLIN2/PLIN3 pathway, which provides novel insights for MAFLD therapy.
Authors
- Hang Du
- Xuetao Zhu (ORCID: https://orcid.org/0000-0002-7563-1603)
- Rong Sun
- Li-song Sheng
- Na-na Huang
- Ying Zhong
- Jia-ying Qi
- Xian-hui Shen
- Jian-chao Li
Institutions
- Tianjin University of Traditional Chinese Medicine (CN)
- Shandong University of Traditional Chinese Medicine (CN)
- Shandong University (CN)
- Second Hospital of Shandong University (CN)
- Qilu Hospital of Shandong University (CN)
Publication Details
- Journal
- Chinese Medicine
- Published
- 2026-01-20
- DOI
- https://doi.org/10.1186/s13020-025-01310-y
- Citations
- 1
- Primary Topic
- Liver Disease Diagnosis and Treatment
- Type
- article
- Field-Weighted Citation Impact
- 31.52