Choosing real-world data for clinical and epidemiological research: methodological lessons from NHIRD and TriNetX—A narrative review

NHIRD and TriNetX are complementary real-world data sources, each with distinct strengths and limitations. Aligning research objectives with database characteristics is essential for appropriate study design. Recognition of platform-specific trade-offs and application of targeted methodological strategies support the validity and generalizability of real-world evidence.

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Publication Details

Journal
Annals of Medicine
Published
2026-01-19
DOI
https://doi.org/10.1080/07853890.2026.2616549
Primary Topic
Health, Environment, Cognitive Aging
Type
article
Field-Weighted Citation Impact
0.00
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article

Choosing real-world data for clinical and epidemiological research: methodological lessons from NHIRD and TriNetX—A narrative review

Yen‐Ju Chen, Teng-Li Lin, Chun-Ying Wu
Annals of Medicine
Health, Environment, Cognitive Aging
article

Choosing real-world data for clinical and epidemiological research: methodological lessons from NHIRD and TriNetX—A narrative review

Yen‐Ju Chen, Teng-Li Lin, Chun-Ying Wu
article en

Abstract

NHIRD and TriNetX are complementary real-world data sources, each with distinct strengths and limitations. Aligning research objectives with database characteristics is essential for appropriate study design. Recognition of platform-specific trade-offs and application of targeted methodological strategies support the validity and generalizability of real-world evidence.

Annals of MedicineVol. 58(1)
National Yang Ming Chiao Tung University (TW), National Chung Hsing University (TW), National Health Research Institutes (TW), Taipei Veterans General Hospital (TW), Taichung Veterans General Hospital (TW), National Defense University (TW), Buddhist Tzu Chi Medical Foundation (US), China Medical University (CN)
Openalex Percentile: Top 85%
Health, Environment, Cognitive Aging
DOIOpen Access PDFOpenAlex
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Choosing real-world data for clinical and epidemiological research: methodological lessons from NHIRD and TriNetX—A narrative review — Yen‐Ju Chen, Teng-Li Lin, et al. · Annals of Medicine (2026) | TGRS Research Map | TGRS