Multiple-Context Training Enhances Generalization of Cued Fear Extinction and Requires the Dorsal Hippocampus
Conducting extinction across multiple contexts enhances acquisition and recall relative to SCFE, without requiring novelty, and engages distinct hippocampal-prefrontal circuit dynamics. dHP activity is necessary for the MCFE-specific improvement, highlighting a circuit mechanism in which distributing extinction across contexts augments fear reduction.
Authors
- Shiv Patel (ORCID: https://orcid.org/0000-0002-9527-7429)
- Victor A. Cazares (ORCID: https://orcid.org/0000-0002-6625-7103)
- Shania Gonzalez
- Eve Hammerman (ORCID: https://orcid.org/0009-0003-1810-633X)
- Carter Roebuck
- Suzanne R Penna
- Gwyneth Maloy
Institutions
- Williams College (US)
Publication Details
- Journal
- bioRxiv (Cold Spring Harbor Laboratory)
- Published
- 2026-01-20
- DOI
- https://doi.org/10.64898/2026.01.18.700199
- Primary Topic
- Memory and Neural Mechanisms
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Williams College
- National Alliance for Research on Schizophrenia and Depression
- National Institutes of Health