Modelling G protein-biased agonism using GLP-1 receptor C-terminal mutations

Genetic changes that reduce β-arrestin recruitment and slow GLP-1R internalisation can enhance GLP-1R signalling, providing conceptual support for the use of G protein bias to improve GLP-1R agonist efficacy.

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Publication Details

Journal
Molecular Metabolism
Published
2026-01-20
DOI
https://doi.org/10.1016/j.molmet.2026.102321
Primary Topic
Diabetes Treatment and Management
Type
article
Field-Weighted Citation Impact
0.00
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article

Modelling G protein-biased agonism using GLP-1 receptor C-terminal mutations

Alice Pollard, Yiming Zuo, Carissa Wong, Steve Bloom et al.
Molecular Metabolism
Diabetes Treatment and Management
article

Modelling G protein-biased agonism using GLP-1 receptor C-terminal mutations

Alice Pollard, Yiming Zuo, Carissa Wong, Steve Bloom, Ben Jones, Hanh Duyen Tran
article en

Abstract

Genetic changes that reduce β-arrestin recruitment and slow GLP-1R internalisation can enhance GLP-1R signalling, providing conceptual support for the use of G protein bias to improve GLP-1R agonist efficacy.

Molecular MetabolismVol. 105
Hammersmith Hospital (GB), Imperial College London (GB)
Openalex Percentile: Top 84%
Diabetes Treatment and Management
DOIOpen Access PDFOpenAlex
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Modelling G protein-biased agonism using GLP-1 receptor C-terminal mutations — Alice Pollard, Yiming Zuo, et al. · Molecular Metabolism (2026) | TGRS Research Map | TGRS