Bile Acids Regulate Accumbal Cholinergic Circuitry and Dopamine Release through TGR5 Activation

Our findings provide evidence that BAs exert direct modulatory effects on neural activity in the striatum.

Authors

Philipp Mews (ORCID: https://orcid.org/0000-0003-2052-1578)
Stephen Thompson (ORCID: https://orcid.org/0000-0001-9637-2041)
Jordan T. Yorgason (ORCID: https://orcid.org/0000-0002-5687-0676)
Isabella A Roque
Shimran S Sharma

Institutions

Brigham Young University (US)
Boston University (US)
University of Maryland, Baltimore (US)
Wake Forest University (US)

Publication Details

Journal: bioRxiv (Cold Spring Harbor Laboratory)
Published: 2026-01-20
DOI: https://doi.org/10.64898/2026.01.16.699938
Primary Topic: Cannabis and Cannabinoid Research
Type: article
Field-Weighted Citation Impact: 0.00

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article

Bile Acids Regulate Accumbal Cholinergic Circuitry and Dopamine Release through TGR5 Activation

Philipp Mews, Stephen Thompson, Jordan T. Yorgason, Isabella A Roque et al.

Jan 20, 2026

bioRxiv (Cold Spring Harbor Laboratory)

Cannabis and Cannabinoid Research

article

Bile Acids Regulate Accumbal Cholinergic Circuitry and Dopamine Release through TGR5 Activation

Philipp Mews, Stephen Thompson, Jordan T. Yorgason, Isabella A Roque, Shimran S Sharma

January 20, 2026article en

Abstract

Our findings provide evidence that BAs exert direct modulatory effects on neural activity in the striatum.

bioRxiv (Cold Spring Harbor Laboratory)

Brigham Young University (US), Boston University (US), University of Maryland, Baltimore (US), Wake Forest University (US)

Openalex Percentile: Top 82%

Cannabis and Cannabinoid Research

DOI Open Access PDF OpenAlex

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Bile Acids Regulate Accumbal Cholinergic Circuitry and Dopamine Release through TGR5 Activation — Philipp Mews, Stephen Thompson, et al. · bioRxiv (Cold Spring Harbor Laboratory) (2026) | TGRS Research Map | TGRS