Comparative safety and efficacy of levosimendan versus dobutamine in acute heart failure: a systematic review, meta-analysis, and meta-regression
Levosimendan demonstrates favorable effects on mortality and key hemodynamic parameters in patients with AHF, especially those on β-blockers or with impaired left ventricular function. Although certain adverse effects like hypotension were more frequent, the overall safety profile remained comparable to dobutamine. These findings suggest levosimendan as a safer and more effective alternative in selected high-risk heart failure populations.
Authors
- Suhail M. Ali
- Mukesh Kumar (ORCID: https://orcid.org/0009-0008-1702-4064)
- Biruk Demisse Ayalew (ORCID: https://orcid.org/0009-0006-8285-6233)
- Laiba Khurram (ORCID: https://orcid.org/0009-0009-1464-701X)
- Neeraj Kumar (ORCID: https://orcid.org/0009-0004-4528-6513)
- Aayush Chaulagain (ORCID: https://orcid.org/0009-0008-0010-6071)
- Laiba Sanober
- Syeda Warisha
- Hammad Rao
- Laksh Kumar
- Adarsh Raja
- Tehreem Saeed
- Mahnoor Saeed
- Iqra Mustafa
- Sania Gulfaraz
- Muqaddas Parvez
- Abdullah
- Tabasum
Institutions
- Liaquat University of Medical & Health Sciences (PK)
- Patan Academy of Health Sciences (NP)
- Rawalpindi Medical University (PK)
- Abbasi Shaheed Hospital (PK)
- Shaheed Mohtarma Benazir Bhutto Medical University (PK)
- Dow University of Health Sciences (PK)
- St. Paul's Hospital Millennium Medical College (ET)
Publication Details
- Journal
- Annals of Medicine and Surgery
- Published
- 2026-01-20
- DOI
- https://doi.org/10.1097/ms9.0000000000004706
- Primary Topic
- Heart Failure Treatment and Management
- Type
- article
- Field-Weighted Citation Impact
- 0.00