Evaluation of a Respiratory Syncytial Virus Subunit Vaccine Candidate in IgA-Deficient Mice: Insights into the Role of IgA in Vaccine-Induced Immunity and Protection
Collectively, these findings demonstrate that although tFrsc/TriAdj confers lower airway protection in the absence of IgA, vaccine-induced IgA is critical for upper airway protection, Th1/balanced immune responses, and optimal B cell responses.
Authors
- Liliana González González
- Jourdan Witt
- Mina Zhiani (ORCID: https://orcid.org/0000-0001-5195-7441)
- SYLVIA VAN DRUNEN LITTEL-VAN DEN HURK
Institutions
- University of Saskatchewan (CA)
Publication Details
- Journal
- Vaccines
- Published
- 2026-01-20
- DOI
- https://doi.org/10.3390/vaccines14010097
- Primary Topic
- Respiratory viral infections research
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Innovation Saskatchewan
- Canadian Institutes of Health Research