Missing tissue, missing data: Resolving brain volume loss caused by anti-amyloid therapies
Anti-amyloid drugs modestly slow Alzheimer's disease progression, albeit with uncertainty of sustained benefit, particularly as they cause paradoxical acceleration of brain volume changes. Here, we examine explanations for these volume changes and argue for transparent release of clinical trial data.
Authors
- Scott Ayton (ORCID: https://orcid.org/0000-0002-3479-2427)
- Francesca Alves (ORCID: https://orcid.org/0000-0002-9059-3238)
Institutions
- The University of Melbourne (AU)
- Florey Institute of Neuroscience and Mental Health (AU)
Publication Details
- Journal
- PLoS Medicine
- Published
- 2026-01-20
- DOI
- https://doi.org/10.1371/journal.pmed.1004880
- Primary Topic
- Dementia and Cognitive Impairment Research
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- State Government of Victoria
- Medical Research Council