Allergen extract outperforms molecular components in basophil activation test in a pediatric cohort
In our study population, molecular components had lower capacity than the corresponding extract to activate IgE-sensitized basophils, which partly explain higher rates of true positive extract<sup>+</sup>/component<sup>-</sup> BAT. Component-based BAT can potentially lead to false-negative results, and extract-based should generally be preferred, especially for cow milk.
Authors
- Éric Ballot (ORCID: https://orcid.org/0000-0002-1128-581X)
- Bourgoin-Heck Mélisande
- Aïcha Abbas
- S Pauliat
- P Challier
- Garance Germain
- Nathalie Lambert (ORCID: https://orcid.org/0000-0001-5817-8686)
- A. Lemoine (ORCID: https://orcid.org/0000-0001-8443-7207)
- Nathalie Cottel
- Stéphanie Wanin (ORCID: https://orcid.org/0000-0001-6656-3461)
- S. Choi
- Tahar Khelifi-Touhami
- J. Just (ORCID: https://orcid.org/0000-0002-5646-2429)
- Yannick Chantran (ORCID: https://orcid.org/0000-0002-9778-0044)
- Sarah Saf (ORCID: https://orcid.org/0000-0002-2733-0590)
- Alexandre Chhing
Institutions
- Inserm (FR)
- Université Paris Cité (FR)
- Sorbonne Université (FR)
- Hôpital Armand-Trousseau (FR)
- Assistance Publique – Hôpitaux de Paris (FR)
- Institut de Recherche pour le Développement (FR)
Publication Details
- Journal
- Frontiers in Immunology
- Published
- 2026-01-20
- DOI
- https://doi.org/10.3389/fimmu.2025.1701351
- Primary Topic
- Food Allergy and Anaphylaxis Research
- Type
- article
- Field-Weighted Citation Impact
- 0.00