Combined Mouse Retinal Optoretinography/Electroretinography System to Study Light-Evoked Responses in Animal Models of Retinal Degeneration

The ORG and ERG measurements recorded under various light stimuli reveal the retina's neural function. The ORG and ERG signals from the WT albino and pigmented mice exhibited thickness increments in the ORG and an increase in amplitude of a-waves and b-waves in the ERG, which were linked to phototransduction; however, these signal trends were not observed in the rd10 mice. Therefore, the ORG/ERG system could be an attractive instrument that provides both localized structural and global functional information about the investigated retina, allowing for detailed studies of neural function suppression in animal models of retinal degeneration.