Effects of GS-967, GS-6615 and ranolazine on the responses of the rabbit aorta to adrenergic nerve stimulation
These findings suggest distinct mechanisms of action among I<sub>Na,late</sub> blockers, highlighting the involvement of large-conductance Ca<sup>2+</sup>-activated K<sup>+</sup> channels in GS-967 and GS-6615 effects, and a competitive α<sub>1</sub>-adrenoceptor antagonism for RAN. Taken together, our results indicate that GS-967, GS-6615 and RAN decrease vasoconstrictor responses due to both neural and noradrenaline-induced adrenergic stimuli. We can suggest that the use of GS-967, GS-6615 and Ranolazine may be interesting in clinical procedures involving hyperstimulation of the adrenergic nervous system.
Authors
- Adrián Jorda (ORCID: https://orcid.org/0000-0001-6093-0013)
- José María Vila (ORCID: https://orcid.org/0000-0001-5265-8072)
- Soraya L Valles
- Martin Aldasoro
Institutions
- Universitat de València (ES)
- College of Podiatry (GB)
Publication Details
- Journal
- Frontiers in Physiology
- Published
- 2026-01-20
- DOI
- https://doi.org/10.3389/fphys.2025.1708250
- Primary Topic
- Cardiac electrophysiology and arrhythmias
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Generalitat Valenciana