Segmentation of Grey and White Matter Hyperintensity in Typically Developing Children and Children With Intellectual Disabilities Using Voxel Based Morphometry

The findings indicate that white and grey matter volumes may differ in children with MR compared to healthy controls, and these structures have potential as diagnostic biomarkers. The study demonstrates the developmental heterogeneity of the brain during childhood. However, the limited sample size, the presence of outliers and multicollinearity should be considered as limitations.