Effect of Weight Loss Amplitude Combined with Antiarrhythmic Drugs on Atrial Fibrillation Freedom, as compared to Catheter Ablation: A Sub-Analysis of the PRAGUE-25 Trial

In obese patients, the maintenance of SR on AADs is related to the level of weight reduction. The efficacy of AADs in obese patients with a significant weight loss at 12-months follow-up is close to catheter ablation, although the overall AF burden is still non-significantly higher.

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Publication Details

Journal
EP Europace
Published
2026-01-15
DOI
https://doi.org/10.1093/europace/euag013
Primary Topic
Atrial Fibrillation Management and Outcomes
Type
article
Field-Weighted Citation Impact
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article

Effect of Weight Loss Amplitude Combined with Antiarrhythmic Drugs on Atrial Fibrillation Freedom, as compared to Catheter Ablation: A Sub-Analysis of the PRAGUE-25 Trial

J Jarkovsky, Milan Dusík, Štěpán Havránek, Adam Latiňák et al.
EP Europace
Atrial Fibrillation Management and Outcomes
article

Effect of Weight Loss Amplitude Combined with Antiarrhythmic Drugs on Atrial Fibrillation Freedom, as compared to Catheter Ablation: A Sub-Analysis of the PRAGUE-25 Trial

J Jarkovsky, Milan Dusík, Štěpán Havránek, Adam Latiňák, Dalibor Heřman, Marek Hozman, Ivan Ranič, Otakar Jiravský, Tomáš Roubíček, Veronika Bulková, František Lehár, J SIMEK, Jan Pidhorodecky, Klára Benešová, Hana Zelinková, Jana Hozmanová, Jana Veselá, Zuzana Hejdukova, P Osmancik, Jan Chovancik, Martin Matoulek, Vladimir Tuka, Bogna Jiravska–Godula
article en

Abstract

In obese patients, the maintenance of SR on AADs is related to the level of weight reduction. The efficacy of AADs in obese patients with a significant weight loss at 12-months follow-up is close to catheter ablation, although the overall AF burden is still non-significantly higher.

EP Europace
Charles University (CZ), Masaryk University (CZ), University Hospital Brno (CZ), Krajská Nemocnice Liberec (CZ), Nemocnice Podlesí (CZ), University Hospital Kralovske Vinohrady (CZ), General University Hospital in Prague (CZ)
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Openalex Percentile: Top 85%
Atrial Fibrillation Management and Outcomes
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Effect of Weight Loss Amplitude Combined with Antiarrhythmic Drugs on Atrial Fibrillation Freedom, as compared to Catheter Ablation: A Sub-Analysis of the PRAGUE-25 Trial — J Jarkovsky, Milan Dusík, et al. · EP Europace (2026) | TGRS Research Map | TGRS