Synergistic Enhancement of Non-viral SIRT1 Gene Delivery to Human Skin Equivalents Using Microneedling and Liposomal Vectors
The Lipo-Dermapen platform provides robust proof of concept for the development of high-efficacy, minimally invasive clinical gene therapies. Furthermore, the unexpected efficacy of non-invasive naked plasmid delivery suggests a novel potential for accessible, self-administered dermatological interventions.
Authors
- Takahiro Ishikawa (ORCID: https://orcid.org/0000-0002-5516-7188)
- Wataru Matsunaga (ORCID: https://orcid.org/0009-0000-1129-7661)
- Akinobu Gotoh
- Miki Nakashima
Institutions
- Kobe International University (JP)
- Morinomiya University of Medical Sciences (JP)
- Global Technology Connection (United States) (US)
- Kobe College (JP)
Publication Details
- Journal
- Cureus
- Published
- 2026-01-19
- DOI
- https://doi.org/10.7759/cureus.101876
- Primary Topic
- Advancements in Transdermal Drug Delivery
- Type
- article
- Field-Weighted Citation Impact
- 0.00