The Werner syndrome RECQ helicase as a therapeutic target: new insights
Significant gaps remain in understanding how WRN loss promotes pathogenesis. Filling these conceptual and informational gaps will allow better prediction of tissue-specific adverse effects of WRN helicase inhibition or WRN loss. We highlight important, unanswered questions in WRN biology and newly emerging research and translational opportunities.
Authors
- Raymond J. Monnat (ORCID: https://orcid.org/0000-0001-7638-7393)
- Julia M. Sidorova (ORCID: https://orcid.org/0000-0001-5502-4323)
Institutions
- University of Washington (US)
Publication Details
- Journal
- Expert Opinion on Therapeutic Targets
- Published
- 2026-01-02
- DOI
- https://doi.org/10.1080/14728222.2026.2619753
- Primary Topic
- DNA Repair Mechanisms
- Type
- article
- Field-Weighted Citation Impact
- 0.00