Integrated multi-omics identifies MCRS1 as a causal hub linking aging, metabolic syndrome, and breast cancer progression
This study identifies MCRS1 as a central molecular hub that causally links aging and MetS to BC pathogenesis. MCRS1 is a validated driver of tumor progression and a high-performance biomarker, representing a potential target for therapeutic development, particularly in BC patients with metabolic comorbidities.
Authors
- Yiying Tao
- Jianmin Wu (ORCID: https://orcid.org/0000-0002-0999-9194)
- Jing Du
- Xia Liu (ORCID: https://orcid.org/0000-0002-9209-0562)
- Wei Xuan (ORCID: https://orcid.org/0000-0002-4013-9408)
- Guojun Qian
- Jie Tian
- Hao Zhu
- Xibing Ding
- Yuqing Chen
Institutions
- Shanghai Jiao Tong University (CN)
- Renji Hospital (CN)
Publication Details
- Journal
- International Journal of Surgery
- Published
- 2026-01-20
- DOI
- https://doi.org/10.1097/js9.0000000000004592
- Primary Topic
- Cancer Risks and Factors
- Type
- article
- Field-Weighted Citation Impact
- 0.00