Serum creatinine, genetic susceptibility, and the risk of osteoporosis and fracture: a prospective cohort study from the UK Biobank
Baseline serum creatinine was significantly and nonlinearly associated with incident osteoporosis (U-shaped pattern) and fractures (J-shaped pattern), with the lowest risk observed at approximately 80 μmol/L, and there was a notable sex difference (higher in males). These associations were independent of genetic susceptibility, suggesting that serum creatinine may serve as a low-cost adjunct marker for clinical risk stratification and surveillance of osteoporosis.
Authors
- Huimou Chen
- Qiongyan Liu
- Ke Xu (ORCID: https://orcid.org/0000-0002-9969-3681)
- Heng Zhang (ORCID: https://orcid.org/0000-0002-0103-2173)
- Jiaxuan Ding (ORCID: https://orcid.org/0000-0002-0127-8982)
- Chonghui Hu (ORCID: https://orcid.org/0009-0001-2332-4150)
- Honglin Gu
- Weijie He
- Jiale Jiang
Institutions
- Guangzhou University of Chinese Medicine (CN)
- Sun Yat-sen University (CN)
- Changsha Medical University (CN)
- Third Affiliated Hospital of Guangzhou Medical University (CN)
- Sun Yat-sen Memorial Hospital (CN)
- Affiliated Hospital of Liaoning University of Traditional Chinese Medicine (CN)
- Guangdong Academy of Medical Sciences (CN)
- Guangdong Provincial People's Hospital (CN)
- Qilu Hospital of Shandong University (CN)
- Southern Medical University (CN)
- Guangzhou Medical University (CN)
Publication Details
- Journal
- Frontiers in Endocrinology
- Published
- 2026-01-20
- DOI
- https://doi.org/10.3389/fendo.2025.1727636
- Primary Topic
- Bone health and osteoporosis research
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Natural Science Foundation of Guangdong Province