Five-Year Absolute Risk–Based and Age-Based Breast Cancer Screening in the US

In this decision analytical modeling study of breast cancer screening, population risk-based screening using 5-year invasive breast cancer risk was associated with similar or greater benefits than age-based screening as well as reduced false-positive recalls. As personalized medicine advances, risk-based screening is poised to become a cornerstone of breast cancer prevention, offering a more nuanced and tailored approach to patient care.

Authors

Institutions

Publication Details

Journal
JAMA Network Open
Published
2026-01-20
DOI
https://doi.org/10.1001/jamanetworkopen.2025.52944
Citations
2
Primary Topic
Digital Radiography and Breast Imaging
Type
article
Field-Weighted Citation Impact
72.89
Controls
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article

Five-Year Absolute Risk–Based and Age-Based Breast Cancer Screening in the US

O Alagoz, Rick Groeneweg, Eugenio Gil Quessep, Kathryn P. Lowry et al.
2 citations
JAMA Network Open
Digital Radiography and Breast Imaging
72.89
article

Five-Year Absolute Risk–Based and Age-Based Breast Cancer Screening in the US

O Alagoz, Rick Groeneweg, Eugenio Gil Quessep, Kathryn P. Lowry, Natasha K. Stout, Jeanne S. Mandelblatt, Harry J. de Koning, Brian L. Sprague, Yifan Lu, Clyde B. Schechter, John Hampton, Nicolien T. van Ravesteyn, Karla Kerlikowske, Diana L. Miglioretti, Anna N. A. Tosteson
article en
2 citations

Abstract

In this decision analytical modeling study of breast cancer screening, population risk-based screening using 5-year invasive breast cancer risk was associated with similar or greater benefits than age-based screening as well as reduced false-positive recalls. As personalized medicine advances, risk-based screening is poised to become a cornerstone of breast cancer prevention, offering a more nuanced and tailored approach to patient care.

JAMA Network OpenVol. 9(1)
Dartmouth College (US), University of Vermont (US), Albert Einstein College of Medicine (US), University of Wisconsin–Madison (US), Kaiser Permanente Washington Health Research Institute (US), University of California, San Francisco (US), Georgetown University (US), Georgetown University Medical Center (US), Erasmus MC (NL), Fred Hutch Cancer Center (US), University of Wisconsin Carbone Cancer Center (US), Dartmouth Psychiatric Research Center (US), National Cancer Institute (US)
Openalex Percentile: Top 0%
Digital Radiography and Breast Imaging
72.89
DOIOpen Access PDFOpenAlex
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Five-Year Absolute Risk–Based and Age-Based Breast Cancer Screening in the US — O Alagoz, Rick Groeneweg, et al. · JAMA Network Open (2026) | TGRS Research Map | TGRS