Pyrene‐Conjugated, 2‐Pyridinecarboxaldehyde Derivatives as N‐Terminus‐Specific Tags for MALDI‐ and LALDI‐MS
This study presents the first presentation and characterization of this novel pyr-2PCA tag, thereby laying the groundwork and demonstrating its future potential for MALDI/LALDI-based in situ spatial N-terminomics to study proteolytic processes.
Authors
- Nadine Meier
- Mujia Li
- Murat Kücükdisli (ORCID: https://orcid.org/0000-0002-7389-6704)
- Bettina Wehrle
- Florian Braun
- David W. Will
- Melanie Christine Föll
- Larissa Chiara Meyer
- Oliver Schilling
Institutions
- University of Freiburg (DE)
- German Cancer Research Center (DE)
- Heidelberg University (DE)
- University Medical Center Freiburg (DE)
- European Molecular Biology Laboratory (DE)
Publication Details
- Journal
- Rapid Communications in Mass Spectrometry
- Published
- 2026-01-20
- DOI
- https://doi.org/10.1002/rcm.70034
- Primary Topic
- Mass Spectrometry Techniques and Applications
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Deutsche Forschungsgemeinschaft
- Bundesministerium für Bildung und Forschung