Compromised hepatic bilirubin clearance drives depressive symptoms via regulating microglial engulfment of dendritic spines
Our results reveal a novel liver-brain pathway whereby impaired bilirubin clearance drives depression via microglial synaptic pruning. Targeting microglial TRPM2 offers a promising therapeutic strategy for MDD.
Authors
- Tianyue Yin
- Shiyuan Zhang (ORCID: https://orcid.org/0000-0001-5333-2568)
- Kan He
- Chengjun Xu
- Sheng Wang
- Xiangru Liu
- Zhong Li
- Shuaijie Sun
- Jiaming Zhang
- Li Wang
- Hongrui Zhu
- Mengmeng Yang
- Mengyu Li
- Xinlu Yang
- Jun Ma
- Chunliu Li
Institutions
- University of Science and Technology of China (CN)
- Hefei National Center for Physical Sciences at Nanoscale (CN)
Publication Details
- Journal
- Journal of Neuroinflammation
- Published
- 2026-01-20
- DOI
- https://doi.org/10.1186/s12974-025-03685-z
- Primary Topic
- Heme Oxygenase-1 and Carbon Monoxide
- Type
- article
- Field-Weighted Citation Impact
- 0.00