Comparison of Clinical Outcomes After Cataract Surgery with Implantation of Either a Partial-Depth of Field Extended or Monofocal Intraocular Lens

<b>Background/Objectives</b>: To compare the clinical outcomes following cataract surgery with implantation of a new partial depth of field (DOFi) intraocular lens (IOL) versus a monofocal IOL of identical material, platform, and haptic design. <b>Methods</b>: Single-center, non-randomized trial including 55 patients randomly assigned to be implanted either with the partial-DOFi IOL Tecnis PureSee (partial-DOFi group, 29 patients) or the Tecnis monofocal IOL DCB00/ZCU (both Johnson & Johnson Surgical Vision) (monofocal group, 26 patients). Monocular visual acuity (VA), refractive, binocular defocus curve, and patient-reported outcomes (QoV and Catquest 9SF questionnaires) were evaluated during a 3-month follow-up. <b>Results</b>: No significant differences between monofocal and partial-DOFi groups were found in monocular postoperative uncorrected- (0.03 ± 0.08 vs. 0.05 ± 0.10, <i>p</i> = 0.419) and corrected-distance VA (-0.03 ± 0.04 vs. -0.03 ± 0.05, <i>p</i> = 0.642). Significantly better distance-corrected intermediate VA was found in the partial-DOFi group (0.29 ± 0.08 vs. 0.10 ± 0.06, <i>p</i> < 0.001). Similarly, postoperative monocular distance-corrected near VA was better in the partial-DOFi group (0.51 ± 0.10 vs. 0.31 ± 0.09, <i>p</i> < 0.001). In the defocus curve, significantly better distance-corrected VAs compared to monofocal were found for all defocus levels from -1.50 to -4.00 D. Minor reports of starbursts were found in both IOL groups. With the Catquest questionnaire, some significant differences were found between groups including reduced difficulty reading newspapers (<i>p</i> < 0.001), improved visibility of prices while shopping (<i>p</i> < 0.001) and enhanced performance of hobbies (<i>p</i> = 0.030) and needlework (<i>p</i> < 0.001). <b>Conclusions</b>: The partial-DOFi IOL evaluated demonstrates superior intermediate and near visual performance compared to a monofocal IOL, while maintaining equivalent distance vision and visual quality.