Panax notoginseng saponins ameliorate spinal cord injury by inhibiting JAK2/STAT3-mediated macrophage polarization: Enhanced delivery by ultrasound-targeted microbubble destruction
PNS inhibits JAK2/STAT3 to promote M2 polarization and reduce apoptosis. UTMD amplifies PNS's efficacy, providing a novel SCI therapy strategy.
Authors
- Jiaojiao Zhou
- Miao Fang
- Shu Luo
- Keyu Xie
- Xuelian Chen
- Yin Shi
- Anjie Chen
Institutions
- Sichuan University (CN)
- West China Second University Hospital of Sichuan University (CN)
- West China Hospital of Sichuan University (CN)
- Chengdu Second People's Hospital (CN)
Publication Details
- Journal
- Phytomedicine
- Published
- 2026-01-20
- DOI
- https://doi.org/10.1016/j.phymed.2026.157856
- Primary Topic
- Ginseng Biological Effects and Applications
- Type
- article
- Field-Weighted Citation Impact
- 0.00